Which is Better Omeprazole or Pantoprazole?

Omeprazole and Pantoprazole are two common drugs recommended for treating acid influx. Both drugs are also used in the treatment of indigestion, heartburn, along with other stomach-acid related conditions.

About Omeprazole

Omeprazole belongs to a group of medications known as proton pump inhibitors. The drug relieves acid influx by decreasing the amount of acid produced in the stomach. This action promotes the healing of gastric and duodenal ulcers and other inflamed gastrointestinal tissue areas.

The drug has been used to treat various stomach acid-related conditions including Barrett’s Esophagus, GERD, Erosive Esophagitis, Duodenal Ulcer, Indigestion, Helicobacter Pylori Infection, Multiple Endocrine Adenomas, Stomach Ulcer, Systemic Mastocytosis, Zollinger-Ellison Syndrome.

On some occasions, omeprazole is prescribed for treating Gastritis/Duodenitis, Hiatal Hernia, Laryngopharyngeal Reflux. Omeprazole (20 mg) is available as oral delayed-release capsules and oral delayed-release tablets. The drug can be purchased on prescription and over the counter.

About Pantoprazole

Pantoprazole is also a proton pump inhibitor. The drug is commonly used treating stomach ulcers, short-term treatment of erosive esophagitis due to gastroesophageal reflux disease. Pantoprazole effectively heals inflamed tissue in the gastrointestinal tract and relieves symptoms of heartburn.

The drug has also been prescribed for Barrett’s Esophagus, GERD, Duodenal Ulcer, Erosive Esophagitis, Gastritis/Duodenitis, Helicobacter Pylori Infection, Peptic Ulcer, Stomach Ulcer, Stress Ulcer Prophylaxis, Zollinger-Ellison Syndrome. Pantoprazole may be prescribed off-label for Dumping Syndrome, Laryngopharyngeal Reflux.

Pantoprazole (40 mg) is available as an intravenous powder for injection and oral delayed-release tablet. Pantoprazole tablets should not be split, crushed, or chewed. Unlike Omeprazole, Pantoprazole is available only on prescription.

The Similarities and Differences Between Omeprazole and Pantoprazole

Because Omeprazole and Pantoprazole belong to the same class of drugs (proton pump inhibitor) they work in a similar fashion. They inhibit proton pumps, the lining in the stomach which responsible for producing the stomach acid. By inhibiting these proton pumps, they reduce the amount of acid produced in the stomach.

But both drugs are different in a number of ways. Omeprazole contains 20 mg of Omeprazole as its active ingredient, while Pantoprazole contains 40 mg of Pantoprazole sodium as its active ingredient. Both are generic, and thus, have essentially different inactive ingredients – depending on their branded variants.

Omeprazole and Pantoprazole, which is Better?

There is no yes or no answer to this question. In considering how both work, you would then know which of them is right for you.

  • Firstly, because Pantoprazole can be administered through injections, it works faster than Omeprazole which needs to go through the stomach, intestine, the coating also has to dissolve before it can be absorbed.

  • Pantoprazole is slightly more acid-stable than omeprazole. The effects are, however, not very significant.

  • Other pharmacokinetic differences include pantoprazole’s oral absorption is better than omeprazole’s.

  • Omeprazole has a longer half-life (90 minutes) than Pantoprazole (60 minutes), so the effects of Omeprazole should last longer.

  • Omeprazole interacts with more drugs (342 known) than Pantoprazole (259). However, Omeprazole interacts with fewer diseases.

The most significant difference between both drugs is that Pantoprazole is also available for administration as an injection. Because of this, it is used for treating severe cases such as acute gastritis with severe vomiting and bleeding peptic ulcers

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